Reveal Pharmaceuticals

The Gadolinium-Free MRI Contrast Agent
The Future of Medical Imaging

Home
.
We all know someone who has had a contrast-enhanced MRI
Over 30 million contrast-enhanced (CE) MRI scans are done worldwide each year.
CE-MRI scans provide vital medical insight informing diagnosis and management of cancer, stroke, multiple sclerosis, myeloma, cardiovascular disease, Crohn's disease and IBD, various genetic disorders, and many other conditions.
Current MRI contrast agents all deposit the heavy metal gadolinium in all patients
All currently approved MRI contrast agents contain the heavy metal gadolinium, which is not naturally found in biology and is toxic in its ionic form. All gadolinium based contrast agents (GBCAs) cause cumulative deposition of gadolinium in the brain, bone, and other organs of all patients. GBCAs also trigger devastating nephrogenic systemic fibrosis in renally impaired patients. Patients at greatest risk include people with renal impairment, children, and people who require repeat CE-MRIs for surveillance, management, or clinical trials.
e.g. BRCA surveillance, multiple sclerosis, cancer, chronic conditions.
Safety concerns led to worldwide regulatory restrictions
Responding to safety concerns, the FDA applied a boxed warning and instituted label changes for all GBCAs. The European Medicines Agency suspended marketing authorizations for the least stable GBCAs and restricted use of other GBCAs. Japan, Korea, Canada, the United Kingdom, and other countries implemented similar restrictions on GBCAs.
No alternatives for crucial contrast-enhanced imaging
CE-MRI provides insights not available using other imaging methods. However, all approved MRI contrast agents are based on gadolinium and face safety concerns. Physicians and patients must make difficult decisions: balancing the need for vital medical imaging with the risks posed by gadolinium.
Reveal’s solution: the gadolinium-free MRI contrast agent
Reveal’s gadolinium-free MRI contrast agent is a direct substitute for GBCAs.
Our agent, RVP-001, is based on the biocompatible essential element manganese.
RVP-001 produces equivalent images to GBCAs for the same indications as GBCAs using established radiology workflow and protocols.
Our goal: safer contrast enhanced MRI for all patients.
Learn more...

Reveal's MRI contrast agent is the gadolinium-free direct replacement for all current GBCAs.

Reveal's MRI contrast agent is designed to be safe for all patients.

Reveal's MRI contrast agent will be the platform for precision imaging.

People

Team
Vera Hoffman
CEO
Co-Founder
Vera Hoffman is the CEO and co-founder of Reveal Pharmaceuticals. She is Principal Investigator on Reveal's two Fast Track SBIR grants, which are funded by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases.
Previously, Vera directed startups and high growth enterprises from idea stage through global scale. She developed the initial business plan for Acquia ($1B exit, 2019); led teams across six continents to identify, plan, and execute new business opportunities for one of the world's largest companies; and guided the design, development, and commercialization of over a dozen innovative technology-based products. Vera has degrees in Chemistry and Mathematics and an MBA from Harvard Business School.
Peter Caravan
Peter is a world leader in MRI contrast agent development and applications, with 20 years industrial and academic experience. He is co-inventor of RVP-001. Peter leads a molecular imaging lab at Massachusetts General Hospital (MGH) focused on contrast agents and molecular probes to image fibrosis and thrombosis, as well as alternatives to GBCAs. At MGH he invented two novel molecular tracers and he holds INDs for their ongoing clinical development. In industry Peter was part of the team that developed the FDA-approved blood pool agent Ablavar® (Gadofosveset), and was co-inventor of the thrombus-specific agent EP-2104R, the first molecular MR imaging probe to enter human clinical trials. Peter is a Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM) and was awarded the 2019 Torsten Almén Award for Pioneering in Contrast Media Research.
Eric Gale
Eric is a chemist with over 10 years’ experience in the synthesis and structural characterization organic and inorganic compounds. He is co-inventor of RVP-001 and was instrumental in the discovery of this contrast agent and its preclinical characterization and synthesis. Eric is the Principal Investigator on three NIH-funded grants. He has a PhD from the University of Georgia and was a NIH-funded Ruth L. Kirschstein National Research Service Award Scholar at the Massachusetts General Hospital.
Srinivasan Mukundan
Medical Director
Srini is a neuroradiologist and chemist whose expertise in Magnetic Resonance Imaging encompasses more than three decades leading magnetic resonance studies in humans, animals, and on chemical systems. Srini serves as the Medical Director of Magnetic Resonance Imaging (MRI) within the Department of Radiology at BrighamHealth, where he is also Chairman of the MR Safety Committee and Co-Director of Clinical Functional MRI, as well as Associate Professor in Radiology at Harvard Medical School. He served as Division Chief of Neuroradiology at the BWH from 2008-2017 and chaired the BWH Contrast Agent Safety Committee from 2009-2018. In addition to extensive clinical, research, and teaching experience, Srini previously worked to develop innovative liposomal MRI contrast agents. Srini has a PhD in bioinorganic chemistry and an MD from Emory University, where he completed all his training.
Christopher Payton
Finance and Administration
Chris is an expert in finance and entrepreneurship, both of which he has taught at Harvard Business School. An author of over thirty Harvard Business School case studies, Chris has also served as a consultant and trainer to central banks, global financial institutions, and multinational corporations. Chris has served as a senior officer of five early-stage businesses and is an active advisor to founders and investors in the Boston area. Chris has a Bachelor of Mathematics from the University of Waterloo and an MBA from Harvard Business School.
John Amedio
Chemistry, Manufacturing, and Controls
John provides technical and regulatory CMC development strategy for biotechnology and pharmaceutical companies working to bring drugs to market. John has over 20 years experience in the pharmaceutical industry: he has delivered profitable and patented pre-clinical through commercial manufacturing processes for drugs including Ablavar®, Arbaclofen, Zinapar™, Zibulin™, Zymafos™, Favipiravir, and multiple NCE’s including peptides and metal-based drugs. John has authored and reviewed CMC sections for numerous regulatory filings (INDs, IMPDs, Amendments, Annual Updates, and NDAs). John has a PhD in organic chemistry from the University of Delaware.
Thomas Steele
Preclinical Pharmacology and Toxicology
Tom is an expert in pharmacology and toxicology, with over 20 years of experience in preclinical development and toxicology of novel small molecule and biological therapeutics in multiple therapeutic areas. Tom has extensive experience in the drug discovery and development process, as well as regulatory document preparation, review, and submission. He had a vital role in multiple successful “first in human” regulatory applications and served as preclinical expert for two initial marketed product approvals. Tom has held positions at the FDA, large pharmaceutical companies (Roche, Eli Lilly) and small biopharma (Ariad). Tom has a PhD in Pharmacology and Toxicology from Purdue University.
Advisors
Scott Reeder MD PhD
Professor, Vice Chair of Research, Chief of MRI: Department of Radiology, University of Wisconsin, Madison
Director, University of Wisconsin Liver Imaging Research Program
Scott is a Professor, Vice Chair of Research and Chief of MRI in the Department of Radiology at the University of Wisconsin, Madison. Scott’s many contributions to radiology include development of quantitative biomarkers in cardiovascular and body MR imaging. Scott is the Director of the UW Liver Imaging Research Program; 2017 Chair of the Safety Committee for the International Society for Magnetic Resonance in Medicine (ISMRM); a Fellow of the ISMRM; a Fellow of the the Society of Computed Body Tomography and Magnetic Resonance (SCBT/MR); and a Fellow of the American Institute for Medical and Biological Engineering (AIMBE).
Gregory Sorensen MD
CEO, DeepHealth
Executive Chairman, IMRIS
Greg is CEO of DeepHealth, and Executive Chairman of IMRIS. Previously he was President and CEO of Siemens Healthcare North America, and prior to that a Professor at Harvard Medical School and Co-Director of the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. A board-certified neuroradiologist, Greg’s scientific career focused on developing new imaging methods to understand cancer of the brain, stroke, and migraine. Greg is a member of the Scientific Council of the National Institutes of Biomedical Imaging and Bioengineering, past Chairman of the Board of the Medical Imaging Technology Alliance, and serves on the Supervisory Board of Siemens Healthineers and the Board of Directors of Research!America.
Michael Tweedle PhD
Professor, Stefanie Spielman Chair in Cancer Imaging: the Ohio State University
Director, Wright Center Molecular Imaging Agents Laboratory, the Ohio State University
Mike is a Professor, Stefanie Spielman Chair in Cancer Imaging in Radiology, and Director of the Wright Center Molecular Imaging Agents Laboratory at The Ohio State University. He previously held the positions of President, Lead Scientist, and Chief Executive of Bracco Research USA. Mike is a ground-breaking and prolific innovator in contrast media: he invented and led translational development of the first generation macrocyclic MRI agent ProHance®; X ray, Optical, and US agents; diagnostic imaging pharmaceuticals for nuclear medicine; and a radiotheranostic. In 1995 Mike was awarded the Harry Fischer Medal for Excellence in Contrast Media Research.

Support

Grants & Awards
Investors


In addition to grants and awards, Reveal's work is supported by impact investors.



Science


Contact

Reveal Pharmaceuticals
The gadolinium-free MRI contrast agent

Cambridge, Massachusetts, USA